Xenglu-Lin (10/5mg) 14 Tablets

Empagliflozin and Linagliptin are the two active ingredients in the tablet you described. Empagliflozin works by inhibiting the sodium-glucose cotransporter 2 (SGLT2) in the kidneys. This inhibition leads to reduced reabsorption of glucose in the kidneys, resulting in increased glucose excretion in urine and subsequent lowering of blood glucose levels. On the other hand, Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It blocks the breakdown of incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which are responsible for stimulating insulin secretion in response to high blood glucose levels. By inhibiting DPP-4, Linagliptin enhances the activity of these incretin hormones, leading to increased insulin secretion, decreased glucagon secretion, and improved blood glucose control.

Empagliflozin 10mg, Linagliptin 5mg

SGLT2 inhibitor, DPP-4 inhibitor.

Tablet

The following are the uses of Empagliflozin 10mg, Linagliptin 5mg Tablet:

• Used for managing type 2 diabetes by lowering blood sugar levels.
• Used to improve glycemic control and reduce the risk of diabetes-related complications.
• Used to promote weight loss and improve blood pressure in diabetic patients.
• Used to enhance insulin sensitivity and reduce insulin resistance.
• Used for protecting the kidneys and reducing the risk of diabetic kidney disease.
• Used to lower the risk of cardiovascular events in diabetic patients with established cardiovascular disease.
• Used to support overall glucose management and metabolic control.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Type 2 diabetes- 10mg of Empagliflozin and 5mg of Linagliptin (if the condition is not controlled with a single drug)
• Heart failure- 10mg of Empagliflozin (once a day)

In the case of an overdose of Empagliflozin 10mg and Linagliptin 5mg Tablet, symptoms may include excessive urination, dehydration, dizziness, and low blood pressure. Promptly seek medical advice if you suspect an overdose, as the severity of symptoms can vary. The doctor may recommend monitoring and supportive care, focusing on managing any resulting dehydration and maintaining stable vital signs. Timely intervention is crucial to ensure the best possible outcome.

In the case of a missed dose of Empagliflozin 10mg and Linagliptin 5mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided there is a sufficient gap before the next scheduled dose. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or asking someone to remind you to take your medication as prescribed.

To take the Empagliflozin 10mg, Linagliptin 5mg Tablet, swallow one tablet daily as directed by your healthcare provider, preferably at the same time each day, with or without food, ensuring you follow the prescribed dosage and duration for optimal effectiveness.

Following are the conditions or situations when Empagliflozin 10mg, Linagliptin 5mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Empagliflozin, Linagliptin, or any other similar medications.
• Contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.
• Not recommended for individuals with severe kidney problems or those on dialysis.
• Should not be used if you have a history of a serious allergic reaction (angioedema) with other similar medications.
• Not suitable for individuals with severe bladder infections or urinary tract infections.
• Should be avoided if you have a condition called 'gallbladder necrosis' or problems with your gallbladder.
• Contraindicated during pregnancy and breastfeeding.
• Should not be used in patients with severe dehydration or those who are unable to produce urine.

The side effects of Empagliflozin 10mg, Linagliptin 5mg Tablet may include:

• Increased urination
• Genital yeast infections
• Urinary tract infections
• Dehydration
• Low blood sugar (hypoglycemia)
• Dizziness or lightheadedness
• Nausea and vomiting
• Skin reactions, such as rash or itching

Following are the precautions and warnings for Empagliflozin 10mg, Linagliptin 5mg Tablet:

• Not recommended for individuals with a known allergy to Empagliflozin, Linagliptin, or related substances.
• Patients with kidney problems should exercise caution, as dosage adjustments might be necessary for those with renal impairment.
• This medication may increase the risk of urinary tract infections and genital yeast infections; patients should be monitored for any signs or symptoms.
• Empagliflozin can cause dehydration and hypotension, especially in patients with impaired renal function or those on a low-salt diet.
• Linagliptin may cause acute pancreatitis, including severe and life-threatening forms; patients should be advised to seek medical attention if they experience persistent, severe abdominal pain.
• Not recommended for patients with type 1 diabetes mellitus or diabetic ketoacidosis.
• Elderly patients may be more susceptible to certain side effects, and dosage adjustments might be required.
• Patients should be educated about the symptoms of hypoglycemia and advised to carry glucose tablets or a fast-acting carbohydrate source.

Following are the drug interactions for Empagliflozin 10mg, Linagliptin 5mg Tablet:

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase the exposure of empagliflozin, potentially requiring dose adjustments.
• Empagliflozin may enhance the effects of diuretics and antihypertensive agents, leading to increased risk of hypotension.
• Linagliptin may increase the risk of hypoglycemia when used with insulin or insulin secretagogues like sulfonylureas or meglitinides.
• The efficacy of linagliptin may be reduced when used with rifampin, a strong CYP3A4 inducer.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the diuretic and antihypertensive effects of empagliflozin.
• Empagliflozin may increase the risk of genital mycotic infections, and concurrent use of immunosuppressants may further increase this risk.
• Caution is advised when combining with other glucose-lowering medications, as it may increase the risk of hypoglycemia.
• Linagliptin may increase digoxin concentrations, requiring monitoring and dose adjustments if necessary.

Following are the food interactions for Empagliflozin 10mg, Linagliptin 5mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of hypoglycemia, especially when combined with the medication's blood sugar-lowering effects.
• Avoid high-potassium foods like bananas, oranges, and tomatoes, as Empagliflozin can increase potassium levels.
• Limit or avoid grapefruit and grapefruit juice as they may affect the metabolism of Linagliptin, altering its effectiveness.
• Be cautious with high-sugar foods and beverages, as the medication may not effectively manage blood sugar spikes.
• Consume a balanced diet with complex carbohydrates, lean proteins, and healthy fats to support overall diabetes management.
• Stay hydrated, as Empagliflozin may increase urine output and lead to dehydration.
• Avoid high-sodium foods to maintain stable blood pressure, as the medication may affect sodium levels.

Empagliflozin 10mg, Linagliptin 5mg Tablet should be stored in a secure and dry location, preferably in its original packaging, at room temperature (68°F to 77°F or 20°C to 25°C). Protect the medication from light and moisture by keeping it in a dark, dry place, ensuring the container is tightly sealed. It is crucial to maintain the medication's integrity by avoiding exposure to high temperatures, so steer clear of storing it in the bathroom or near heat sources like ovens or radiators. Regularly check the expiration date, and dispose of any unused or expired tablets responsibly. Proper disposal methods are essential, so do not flush the medication or throw it into the trash. Consult your pharmacist or local waste disposal company for guidance on how to safely discard pharmaceutical products. Lastly, ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Empagliflozin 10mg, Linagliptin 5mg Tablet:

• Take the tablet as directed by your doctor, typically once daily with or without food.
• Swallow the tablet whole, do not crush or chew it.
• Maintain a consistent routine by taking the medication at the same time each day.
• Stay well-hydrated while taking this medication.
• Monitor your blood sugar levels regularly as advised by your doctor.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Do not stop taking the medication without consulting your healthcare provider.

When taking medicines like Empagliflozin and Linagliptin, it is vital to undergo specific lab tests to assure the medications are adequately maintaining your health and managing your diabetes and kidney disease. The first examination to consider is Blood Sugar Testing, which involves regularly measuring your blood sugar levels to ensure they are within a healthy range. This test allows you to provide your healthcare provider with valuable information if any adjustments are needed in terms of dosage, diet, or exercise to manage your diabetes effectively. Kidney Function Tests, specifically serum creatinine and eGFR (estimated Glomerular Filtration Rate), are crucial for monitoring kidney function. As Empagliflozin can lead to diabetic ketoacidosis in those with kidney problems, these tests become essential for identifying any signs of kidney impairment. A Lipid Profile is the third type of test, measuring cholesterol and triglyceride levels, essential as cardiovascular complications are associated with both diabetes and kidney disease. Regular measures of Weight Monitoring are also pertinent for gaining insight into overall health and determining if adjustments are necessary within your treatment plan, as weight changes can significantly impact diabetes and kidney disease management. Blood Pressure Monitoring is another exam used to maintain healthy blood pressure levels, prevent the worsening of kidney function, and intervene if needed to avoid complications for those with diabetes. The Hemoglobin A1C Test is the last assessment, providing an average of your blood sugar levels for the past few months. This test is instrumental in tracking long-term blood sugar control and assisting in adjusting medication dosages or making lifestyle changes. When undergoing any lab tests, always consult with your healthcare provider, as they may require specific intervals and additional tests based on your individual condition and treatment plan.