Xenglu-Met (12.5/500mg) 28 Tablets

Metformin primarily works by suppressing hepatic glucose production. It inhibits gluconeogenesis and glycogenolysis in the liver, reducing the amount of glucose released into the bloodstream. Metformin also enhances insulin sensitivity in peripheral tissues, particularly in skeletal muscles, where it increases glucose uptake and utilization. Additionally, it may indirectly reduce appetite, leading to decreased food intake and calorie absorption. Empagliflozin, on the other hand, is an SGLT2 (sodium-glucose cotransporter-2) inhibitor. It acts by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in urine. This mechanism lowers blood glucose levels by reducing renal glucose reabsorption and promoting glucosuria, which helps improve glycemic control. Empagliflozin also promotes mild weight loss by eliminating excess glucose from the body.

SGLT2 inhibitor, Biguanide.

Tablet

The following are the uses of Metformin 500mg, Empagliflozin 12.5mg Tablet:

• Used for controlling blood sugar levels in patients with type 2 diabetes.
• Used to reduce the risk of cardiovascular events in diabetic patients.
• Used to aid in weight loss and improve insulin sensitivity.
• Used to lower the chances of diabetic kidney disease progression.
• Used to enhance glycemic control and promote better overall diabetes management.
• Used to support a healthy cardiovascular system in diabetic individuals.
• Used to regulate fluid balance and blood pressure.

In the case of an overdose of Metformin 500mg and Empagliflozin 12.5mg Tablet, it is important to recognize the potential symptoms. These may include nausea, vomiting, abdominal pain, and in severe cases, lactic acidosis. If an overdose is suspected, immediate medical advice should be sought. Prompt treatment can help manage symptoms and prevent further complications, ensuring the best possible outcome for the patient. It is crucial to act quickly and not delay seeking professional medical assistance.

In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Empagliflozin 12.5mg, if a dose is missed, take it as soon as you remember, unless it's near the time for your next dose. In this case, skip the missed dose and continue with your regular dosing schedule. It is advisable to consult your healthcare professional for specific instructions regarding missed doses, especially if you miss multiple doses or if you're unsure about how to manage missed doses.

To take the Metformin 500mg and Empagliflozin 12.5mg Tablet, swallow one tablet whole with a full glass of water, preferably during or after a meal, once daily as directed by your healthcare provider, ensuring not to break, crush, or chew the tablet.

Following are the conditions/situations when Metformin 500mg and Empagliflozin 12.5mg Tablet should not be used:

• Not suitable for individuals with a known allergy to Metformin or Empagliflozin, or any of the tablet's components.
• Should not be used in patients with severe kidney disease or those on dialysis.
• Contraindicated in individuals with diabetic ketoacidosis.
• Not recommended for patients with a history of a serious allergic reaction to sulfonylurea or sulfonamide medications.
• Should not be used if you have recently had a heart attack, stroke, or severe blood circulation problems.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with liver disease or severe liver problems.
• Should not be taken if you are dehydrated or have a severe infection, as it may increase the risk of kidney problems.
• Not recommended for individuals with type 1 diabetes.

The side effects of Metformin 500mg and Empagliflozin 12.5mg Tablet may include:

• Nausea and vomiting
• Diarrhea or stomach pain
• Headache
• Dizziness or lightheadedness
• Increased urination
• Genital yeast infections
• Low blood sugar (hypoglycemia)
• Metallic taste in the mouth

Following are the precautions and warnings for Metformin 500mg, Empagliflozin 12.5mg Tablet:

• Patients with a known allergy to Metformin or Empagliflozin should not take this medication.
• It is crucial to monitor kidney function regularly during treatment, especially in older adults and those with kidney disease.
• This medication can cause a rare but serious condition called lactic acidosis. Discontinue use and seek medical attention if symptoms such as weakness, nausea, vomiting, stomach pain, and rapid breathing occur.
• Patients with a history of liver problems should exercise caution and inform their healthcare provider, as Metformin may affect liver function.
• Alcohol consumption should be avoided or limited while taking this medication, as it can increase the risk of lactic acidosis.
• Patients should be aware of the risk of hypoglycemia, especially when combined with other diabetes medications, and monitor blood sugar levels regularly.
• Individuals with a history of heart or blood vessel problems should be cautious, as Empagliflozin may increase the risk of these conditions.
• Patients should not abruptly stop taking this medication without consulting their healthcare provider, as it may affect blood sugar control.

Following are the drug interactions for Metformin 500mg, Empagliflozin 12.5mg Tablet:

• Combined use with other blood glucose-lowering medications like insulin or sulfonylureas may increase the risk of hypoglycemia.
• Alcohol consumption can increase the risk of lactic acidosis, a rare but serious side effect of Metformin.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might reduce the effectiveness of Empagliflozin in lowering blood glucose.
• Empagliflozin can enhance the effects of certain antihypertensive medications, leading to a greater drop in blood pressure.
• Angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) may increase the risk of hypotension when used with Empagliflozin.
• Drugs that affect kidney function could potentially alter the elimination of Empagliflozin.
• Corticosteroids may counteract the blood glucose-lowering effect of Empagliflozin.

Following are the food interactions for Metformin 500mg and Empagliflozin 12.5mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, especially with Metformin.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the blood sugar-lowering effect of Empagliflozin.
• Maintain a balanced diet with consistent carbohydrate intake to avoid fluctuations in blood sugar levels.
• Avoid high-sugar and high-fat foods as they can counteract the benefits of Metformin and Empagliflozin.
• Limit caffeine intake, especially from coffee and energy drinks, as it can affect blood sugar control.
• Avoid herbal supplements like garlic, ginseng, and bitter melon, which may interact with blood sugar regulation.
• Follow a healthy eating pattern as recommended by your healthcare provider to optimize the medication's effectiveness.

Metformin 500mg and Empagliflozin 12.5mg tablets should be stored in a cool, dry place, preferably at room temperature, away from excessive heat and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to light. It is crucial not to store the tablets in the bathroom or kitchen, as humidity and temperature changes can impact their effectiveness. When disposing of unused or expired tablets, do not discard them in household waste or flush them; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental consumption.

Following are the quick tips for Metformin 500mg and Empagliflozin 12.5mg Tablet:

• Consult your doctor before starting or stopping this medication.
• Take the tablet as directed by your healthcare professional, typically with meals.
• Swallow the tablet whole; do not crush or chew it.
• Maintain a consistent medication schedule for better control of blood sugar levels.
• Avoid alcohol consumption as it may increase the risk of side effects.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.