Xenglu-Met (5/850mg) 14 Tablets

Metformin 850mg primarily works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits gluconeogenesis by suppressing the production of glucose in the liver, leading to lower blood glucose levels. On the other hand, Empagliflozin 12.5mg, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, blocks the reabsorption of glucose in the kidneys, promoting the excretion of glucose in urine. This dual mechanism of action helps lower blood glucose levels by reducing both hepatic glucose output and enhancing glucose elimination through the kidneys.

SGLT2 inhibitor and Biguanide.

Tablet

The following are the uses of Metformin 850mg, Empagliflozin 12.5mg Tablet:

• Used for managing type 2 diabetes by lowering blood sugar levels.
• Used to improve insulin sensitivity, allowing the body to use insulin more effectively.
• Used to reduce the amount of glucose produced by the liver.
• Used to decrease blood sugar absorption in the intestines, further stabilizing blood sugar levels.
• Used to lower the risk of cardiovascular events, such as heart attacks and strokes, in diabetic patients.
• Used for promoting weight loss and improving overall metabolic health.
• Used to enhance kidney function and reduce the progression of kidney disease in diabetic patients.
• Used for its potential anti-inflammatory and antioxidant properties, which may contribute to overall health and disease management.

To be taken as per doctor's prescription

In the case of an overdose of Metformin 850mg and Empagliflozin 12.5mg Tablet, it is important to act promptly. Symptoms may include severe nausea, vomiting, and diarrhea, as well as a rapid heart rate and decreased blood pressure. If an overdose is suspected, seek medical advice immediately. Emergency treatment may involve gastric lavage, supportive care, and monitoring of vital signs. Prompt action can help mitigate the potentially severe consequences of an overdose.

In the case of a missed dose of Metformin 850mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. For Empagliflozin 12.5mg, if you miss a dose, take it as soon as you remember, but if it's closer to the time of your next dose, skip the missed dose and resume your regular dosing schedule. It's important not to double the dose to catch up.

To take Metformin 850mg and Empagliflozin 12.5mg tablets, swallow one tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, once daily at the same time each day.

Following are the conditions/situations when Metformin 850mg and Empagliflozin 12.5mg Tablet should not be used:

• Not suitable for patients with a known allergy to Metformin, Empagliflozin, or any other similar medications.
• Should not be used in individuals with severe kidney disease or those with a history of diabetic ketoacidosis.
• Contraindicated in patients with a history of a serious allergic reaction (angioedema) to any drug in this class.
• Not recommended for individuals with a history of liver disease or severe liver problems.
• Should be avoided in patients with a recent history of heart attack, stroke, or severe blood circulation problems.
• Not suitable for individuals with type 1 diabetes.
• Must not be used if you are on a low-sugar diet or if your diet is changing.
• Avoid if you have an infection or are dehydrated, as it may increase the risk of kidney problems.

The side effects of Metformin 850mg, Empagliflozin 12.5mg Tablet may include:

• Nausea and vomiting
• Diarrhea or stomach pain
• Loss of appetite
• Metallic taste in the mouth
• Increased urination
• Genital yeast infections
• Dizziness or lightheadedness
• Low blood sugar (hypoglycemia)

Following are the precautions and warnings for Metformin 850mg, Empagliflozin 12.5mg Tablet:

• This medication is not recommended for individuals with a known allergy to Metformin or Empagliflozin.
• Patients with kidney or liver disease should exercise caution and consult their doctor, as dosage adjustments may be necessary.
• Alcohol consumption should be avoided or limited while taking this medication, as it may increase the risk of side effects.
• Patients with a history of diabetic ketoacidosis should be closely monitored, as Empagliflozin can increase the risk of this condition.
• Elderly patients may be more susceptible to the side effects of this medication, especially those related to kidney function.
• Patients should be aware of the risk of dehydration and take necessary precautions, especially in hot weather or during intense exercise.
• Those with a history of urinary tract infections or genital infections should exercise caution, as Empagliflozin can increase the risk of these infections.
• Regular monitoring of kidney function and blood glucose levels is recommended while taking this medication.

Following are the drug interactions for Metformin 850mg and Empagliflozin 12.5mg Tablet:

• Alcohol consumption with metformin may increase the risk of lactic acidosis, especially with excessive alcohol intake or liver disease.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the effectiveness of empagliflozin in lowering blood sugar.
• Empagliflozin may increase the risk of dehydration and hypotension when used with diuretics. Close monitoring is required.
• Certain medications like corticosteroids, beta-agonists, and thiazide diuretics may increase blood glucose levels, requiring dose adjustments.
• Metformin may interact with contrast agents used in medical imaging, increasing the risk of kidney damage. Temporary discontinuation may be needed.
• Drugs that affect kidney function, such as ACE inhibitors or ARBs, may require dose adjustments when used with empagliflozin.
• Caution with other antidiabetic medications as the combination may increase the risk of hypoglycemia. Regular monitoring is essential.

Following are the food interactions for Metformin 850mg and Empagliflozin 12.5mg Tablet:

• Alcohol intake should be limited as it can increase the risk of lactic acidosis, especially in individuals with liver problems or those who are fasting or malnourished.
• Avoid excessive consumption of grapefruit and grapefruit juice as it may alter the blood levels of the medication.
• There is no specific food interaction with Metformin, but a healthy and balanced diet is recommended to manage blood sugar levels effectively.
• Empagliflozin may cause a diuretic effect, so ensure adequate fluid intake to prevent dehydration.
• Avoid high-potassium foods like bananas, oranges, and salt substitutes containing potassium as Empagliflozin can increase potassium levels.
• Monitor blood sugar levels closely when consuming carbohydrates, as Empagliflozin can affect glucose absorption.
• There is no significant interaction with food, but take the tablet with a glass of water as instructed by your doctor.

The storage and disposal of Metformin 850mg and Empagliflozin 12.5mg tablets should be carefully considered to maintain their integrity and ensure safety. Keep the tablets in a cool, dry place, preferably at room temperature, and protect them from light and moisture. Store them in their original container, tightly sealed, to maintain their quality and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storage in bathrooms or near heat sources. Always check the expiration date, and if the medication is no longer needed or has expired, consult a pharmacist or healthcare provider for appropriate disposal methods. Do not flush or pour the tablets down the drain; proper disposal is essential to protect the environment. Keep the medication securely stored away from children to prevent accidental consumption.

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Following are the quick tips for Metformin 850mg and Empagliflozin 12.5mg Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the medication as directed, with or without food, but maintain consistency.
• Do not crush or chew the tablet; swallow it whole with a full glass of water.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Do not double the dose to make up for a missed one; continue your regular schedule.
• Store the medication in a cool, dry place, away from sunlight and moisture.
• Inform your doctor about any other medications or supplements you're taking.