Xiga (5mg) 14 Tablets

Dapagliflozin is a medication used to treat type 2 diabetes and is not limited to just that. It functions as a sodium-glucose co-transporter 2 (SGLT-2) inhibitor which helps control blood sugar levels by inhibiting glucose reuptake by the kidneys, reducing excessive glucose production in the liver and increasing glucose uptake and excretion by the kidneys. This helps lower blood sugar levels and assists in weight loss. Dapagliflozin is typically administered as a tablet that is orally taken. The average dosage ranges between 5-10mg and depends on the severity of the case and patient response to the drug. It is not typically used with other diabetic medications unless prescribed by a doctor. It is also important to be aware of the side effects that this medication may induce, including potential risks of diabetic ketoacidosis and infections.

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SGLT2 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Treating type 2 diabetes mellitus in adults
• Helping to prevent serious complications of diabetes such as kidney damage

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Diabetes mellitus type 2- Adults- 5 mg once daily in the morning with or without food. Adolescents aged 17–18 years- 5 mg once daily in the morning with or without food
• Diabetes mellitus type 1- Adults and adolescents aged 17–18 years- Not recommended
• Heart failure- Adults- 5 mg once daily in the morning with or without food

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An overdose of Dapagliflozin 5mg could potentially lead to symptoms such as low blood pressure, dizziness, or slowed heart rate. It is crucial in such an event to immediately seek medical attention. The treatment sought may include supportive care, which monitors vital signs, manages any symptoms, and rectifies any imbalances of electrolytes. In order to absorb the excess drug in the stomach, activated charcoal may be administered. To induce bowel movements and eliminate the drug from the body, laxatives may be used. The specific treatment approach depends on the particular symptoms and the severity of the overdose. It is necessary for medical personnel to assess and decide on the appropriate interventions.

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If you happen to miss a dose of Dapagliflozin, you should take it as soon as you can, but if you remember close to the time of your next scheduled dose, it is advised to skip the missed dose and take the next one as per the schedule. It is wise to follow the instructions of your medical professional on dosing scheduling. Do not take double doses to catch up on the missed dose.It is important to keep up with your dosing schedule to ensure you get the most from your medication. If you miss many doses or keep skipping doses, you should inform your doctor. They may be able to offer tips or adjustments to help you remember or they might choose to change your prescription. It is crucial to follow the directions provided by your medical professional and take your medication regularly to ensure the treatment is effective.

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Before starting your medication, always read the medication guide provided by your pharmacist. If you have any questions, be sure to ask your doctor or pharmacist. It is recommended to take Dapagliflozin 5mg tablets orally, with or without food, usually once a day in the morning with a meal. Swallow the tablet whole, do not crush, chew, or break the tablet. If you are unable to swallow the tablet whole, consult your doctor or pharmacist for advice. The dosage is tailored to your medical condition, response to treatment, and use of interacting medications. Be sure to inform your doctor and pharmacist about all the products you use, including prescription drugs, over-the-counter medicines, and herbal products to avoid any potential interactions. To get the most benefit, take the medication regularly and at the same time every day. If you miss a dose, take it as soon as you remember if it is within 12 hours of the missed dose. If it is longer than 12 hours since the missed dose, skip the missed dose and continue with your regular schedule. It is important to continue taking this medication even if you feel well, sudden stopping may result in a relapse of your condition. Do not stop taking this medication without consulting your doctor. It is especially important to inform your doctor or pharmacist about other medications you are taking, particularly other medications for diabetes, such as insulin or metformin. Should adjustments to the dosage be required, your doctor will be able to advise you.

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Discerning instances where this medication may not be appropriate:

• Allergic reaction to the drug or any of its ingredients
• Severe renal (kidney) impairment or inability to properly remove waste products from the body
• Severe diarrhea, vomiting, or abdominal pain or signs of dehydration such as decreased urine output, dry mouth, thirst, or dizziness when standing up from a sitting or lying position
• Severe disorders of the pancreas, liver, or kidneys
• History of diabetic ketoacidosis (DKA)
• Any condition that would compromise glucose levels, such as severe infection, stroke, trauma, or history of cardiovascular collapse
• Renal or cardiac (heart) bypass surgery
• Pregnancy or planning to become pregnant or breastfeeding
• It is crucial to seek further information from a medical professional before taking this medication, as it can harm an unborn baby.

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Unraveling the side effects lurking behind this medications are as follows:

• Dapagliflozin 5mg side effects
• Increased risk of acute kidney injury
• Decreased blood pressure and syncope (fainting)
• Allergic reactions
• Upper respiratory tract infection
• Diarrhea
• Fatigue
• Joint pain
• Bladder cancer

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Patients should be cautious and consider the following precautions and warnings before initiating treatment:

• Not recommended for patients with an eGFR <15 mL/min/1.3 m² or severe hepatic impairment.
• Assess for ketoacidosis immediately if nonspecific symptoms like nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue, or sleepiness occur, regardless of blood glucose levels.
• Stop treatment immediately if diabetic ketoacidosis is suspected or diagnosed. Patients at higher risk of diabetic ketoacidosis include those with low β cell function reserve (e.g., type 2 diabetes patients with low C peptide or latent autoimmune diabetes, or patients with a history of pancreatitis), conditions that lead to restricted food intake or severe dehydration, those with reduced insulin doses, and those with increased insulin requirements due to acute medical illness, surgery, or alcohol abuse.
• Not to be used for patients with type 1 diabetes.
• Evaluate for necrotizing fasciitis if pain, tenderness, erythema, or swelling in the genital or perineal area with fever or malaise occurs. Discontinue and institute prompt treatment if Fournier's gangrene is suspected.
• Consider temporarily interrupting treatment when treating pyelonephritis or urosepsis.
• Use caution in patients with cardiac failure, NYHA class IV, or CKD without diabetes who do not have albuminuria, polycystic kidney disease, glomerulonephritis with flares, or those on recent cytotoxic, immunosuppressive, or immunomodulating renal therapy, or who have received organ transplants.
• Be aware of the risk of lower limb amputations.
• Contains lactose; not suitable for patients with galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption.
• Not recommended during the second or third trimester of pregnancy or while breastfeeding.
• Not for use in children under 18 years or elderly patients aged 65 years and older.

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Drug interactions with dapagliflozin include:

• Diuretics (e.g., furosemide) (may increase the risk of dehydration and hypotension)
• Insulin (e.g., glargine) (may increase the risk of hypoglycemia- monitor blood glucose levels closely)
• Oral hypoglycemic agents (e.g., metformin) (may have additive effects on blood glucose control)
• Renin-angiotensin-aldosterone system inhibitors (e.g., lisinopril) (may increase the risk of hypotension and renal impairment)
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) (may impact renal function and increase the risk of dehydration)
• Other antidiabetic medications (e.g., sulfonylureas) (may enhance the effect on blood glucose lowering)
• CYP3A4 inhibitors (e.g., ketoconazole) (no significant interaction, but monitor for potential changes in efficacy)
• CYP3A4 inducers (e.g., rifampin) (may affect the metabolism and efficacy of dapagliflozin)

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Dapagliflozin is a medication that needs to be stored at room temperature in a dry place. It is important to avoid exposing it to heat, open flames, or direct sunlight. The medication should never be transferred to another container unless your pharmacist instructs you to do so. You must always keep it out of the reach of children and pets. Make sure to discard the medication according to the instructions on the packaging or as advised by your physician or pharmacist. Storing dapagliflozin properly ensures that it remains effective and safe for use. Remember not to stop taking dapagliflozin without discussing it with your doctor first, even if you feel better.

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