Xyquil DR (10/10mg) 30 Tablets

Doxylamine Succinate is an antihistamine that primarily exerts its effects through antagonizing histamine H1 receptors. By blocking these receptors, doxylamine reduces histamine-induced symptoms such as sneezing, itching, and nasal congestion. It also possesses anticholinergic properties, leading to sedative effects and potential drying of respiratory secretions. Pyridoxine Hydrochloride, also known as vitamin B6, plays a crucial role in various physiological processes. It functions as a coenzyme in the synthesis of neurotransmitters like serotonin and norepinephrine, contributing to its effectiveness in alleviating nausea and vomiting. Pyridoxine supports the metabolism of amino acids and helps maintain a healthy nervous system, thereby enhancing the overall therapeutic action of the medication.

Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg

Antihistamine and Vitamin B6

Tablet

The following are the uses of Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet:

• Used for managing nausea and vomiting during pregnancy
• Used to treat morning sickness and associated symptoms
• Used to provide relief from nausea and vomiting caused by motion sickness
• Used to alleviate symptoms of vertigo and dizziness
• Used to induce sleep and treat temporary insomnia
• Used to reduce symptoms of hay fever and allergic rhinitis
• Used to relieve occasional sleeplessness and improve sleep quality
• Used to provide short-term relief from symptoms of upper respiratory allergies

In the case of an overdose of Doxylamine Succinate 10mg and Pyridoxine Hydrochloride 10mg Tablets, individuals may experience symptoms such as severe drowsiness, confusion, blurred vision, rapid heartbeat, and in extreme cases, seizures or loss of consciousness. It is important to seek medical assistance promptly if an overdose is suspected. Treatment may involve supportive care, monitoring vital signs, and managing any severe symptoms that arise to prevent further complications.

In the case of a missed dose of Doxylamine Succinate 10mg and Pyridoxine Hydrochloride 10mg Tablet, take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice on how to safely adjust your medication routine.

To take Doxylamine Succinate 10mg and Pyridoxine Hydrochloride 10mg tablets, swallow the tablet whole with a glass of water, preferably at bedtime or as directed by your healthcare provider.

Following are the conditions/situations when Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Doxylamine Succinate, Pyridoxine Hydrochloride, or any of the tablet's components.
• Contraindicated in patients with a history of breathing problems or asthma.
• Not recommended for individuals with narrow-angle glaucoma.
• Should not be used in patients with severe liver impairment or liver disease.
• Contraindicated in people with urinary retention or an enlarged prostate.
• Not suitable for individuals with a history of gastrointestinal obstruction or bowel obstruction.
• Avoid using this medication if you have high blood pressure that is not controlled.
• Should not be taken if you have a history of seizures or epilepsy.
• Contraindicated in patients with porphyria, a rare genetic disorder.
• Do not use this medication if you have a blood disorder or bone marrow depression.

The side effects of Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Constipation
• Urinary retention
• Confusion, especially in older adults
• Increased sensitivity to sunlight
• Skin rash or itching

Following are the precautions and warnings for Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet:

• This medication should not be used in patients with known hypersensitivity or allergy to doxylamine succinate or pyridoxine hydrochloride.
• Patients with narrow-angle glaucoma should not take this medication as it may worsen their condition.
• Caution is advised in individuals with a history of respiratory issues, such as asthma or chronic obstructive pulmonary disease (COPD), as doxylamine may cause respiratory depression.
• It may cause drowsiness and impair your ability to drive or operate machinery. Avoid such activities until you know how this medication affects you.
• Alcohol consumption should be avoided as it can increase the sedative effects of doxylamine.
• Elderly patients may be more sensitive to the side effects, especially dizziness and confusion. Regular monitoring is recommended.
• This medication should be used with caution in pregnant and breastfeeding women only if the potential benefits outweigh the risks.

Following are the drug interactions for Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, opioids) can enhance sedation and respiratory depression, potentially leading to serious adverse effects.
• Doxylamine may reduce the effectiveness of certain medications used for Parkinson's disease, such as levodopa, due to its anticholinergic properties.
• Pyridoxine (vitamin B6) can reduce the efficacy of levodopa in Parkinson's disease when taken in high doses.
• Antihistamines, including doxylamine, can potentially interfere with skin allergy tests, producing false-negative results.
• Monoamine oxidase inhibitors (MAOIs) may interact with doxylamine, increasing the risk of side effects such as confusion, hallucinations, and increased blood pressure.
• Doxylamine may increase the effects of certain antidepressants, particularly tricyclic antidepressants, leading to increased sedation and anticholinergic effects.
• Anticonvulsants like phenytoin and carbamazepine may reduce the effectiveness of doxylamine.

Following are the food interactions for Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can inhibit the CYP2D6 enzyme, potentially leading to increased drug levels in the body.
• Alcohol is best avoided as it may enhance the sedative effects of Doxylamine Succinate, increasing the risk of dizziness and drowsiness.
• Consuming high-fat meals might delay the absorption of Pyridoxine Hydrochloride, affecting its effectiveness.
• Caffeine intake should be monitored as it can potentially decrease the efficacy of Doxylamine Succinate in promoting sleep.
• Avoid eating large amounts of foods rich in pyridoxine (vitamin B6), such as fortified cereals, organ meats, and certain fish, as it may lead to excessive vitamin B6 levels when combined with Pyridoxine Hydrochloride from the medication.
• Keep a balanced diet to ensure the medication's effectiveness, especially focusing on foods rich in B-vitamins and minerals like magnesium and potassium.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions or recommendations while taking this medication.

Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablets should be stored in a secure location, away from direct sunlight and moisture, at room temperature. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid storing them in bathrooms or near heat sources, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for guidance on proper disposal methods, and keep the medication out of children's reach to prevent accidental consumption. It is important to handle and store these tablets with care to maintain their quality and safety.

Following are the quick tips for Doxylamine Succinate 10mg, Pyridoxine Hydrochloride 10mg Tablet:

• Consult a doctor for personalized advice and prescription.
• Take the tablets as directed by your healthcare provider.
• Swallow the tablets whole with a full glass of water.
• Maintain a consistent schedule for taking the medication.
• Avoid crushing or chewing the tablets for optimal absorption.
• Inform your doctor about any other medications you are taking.
• Store the tablets in a cool, dry place, away from sunlight.
• Do not share your medication with others, even with similar symptoms.