Zeegap (150mg) 14 Capsules

Pregabalin, the active ingredient in the 150mg capsule, primarily exerts its therapeutic effects by binding to specific subunits of voltage-gated calcium channels in the central nervous system. This binding action leads to a modulation of calcium channel function, resulting in decreased release of excitatory neurotransmitters, particularly glutamate, norepinephrine, and substance P. By reducing the excessive release of these neurotransmitters, pregabalin helps to stabilize abnormal neuronal activity, thereby alleviating neuropathic pain, reducing seizure frequency in certain types of epilepsy, and improving the management of specific anxiety disorders. The selective interaction with calcium channels underlies pregabalin's mechanism of action, making it an effective medication for various neurological and psychiatric conditions.

Anticonvulsant / Analgesic

Capsule

The following are the uses of Pregabalin 150mg Capsule:

• Used for managing neuropathic pain, effectively reducing discomfort.
• Used for treating fibromyalgia, improving overall well-being and pain management.
• Used to control seizures in epilepsy, offering stability and seizure reduction.
• Used for alleviating anxiety disorders, promoting a sense of calm and relaxation.
• Used post-surgery to ease acute pain, ensuring a more comfortable recovery period.
• Used for managing spinal cord injuries, aiding in pain relief and improving functionality.
• Used to treat generalized anxiety disorder (GAD), providing relief from excessive worry and tension.
• Used as an adjunct therapy, enhancing the effectiveness of other medications for various conditions.

To be used as per doctor's advice

In the case of an overdose of Pregabalin 150mg Capsules, individuals may experience a range of symptoms including severe drowsiness, blurred vision, slurred speech, and impaired coordination. Excessive overdoses can lead to more serious effects such as respiratory depression, decreased heart rate, and loss of consciousness. It is important to seek medical assistance promptly if an overdose is suspected. Treatment may involve supportive care, monitoring vital signs, and administering appropriate medications to manage symptoms and ensure the individual's safety.

In the case of a missed dose of Pregabalin 150mg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you frequently miss doses, consult your healthcare professional for advice on how to manage your medication routine effectively. Always keep a consistent schedule to ensure the medication's effectiveness.

To take Pregabalin 150mg Capsules, swallow the capsule whole with a full glass of water, usually two or three times a day, or as directed by your healthcare professional, and it can be taken with or without food.

Following are the conditions when Pregabalin 150mg Capsule should not be used:

• Do not take if you are allergic to Pregabalin or any similar medications.
• Avoid if you have a history of severe heart problems or heart disease.
• Should not be used if you have a kidney disorder or are undergoing dialysis.
• Not suitable for individuals with a history of drug abuse or addiction.
• Contraindicated in patients with a history of angioedema (swelling of deep skin layers) with previous Pregabalin use.
• Do not use if you have a known hypersensitivity to any inactive ingredients in the medication.
• Should be avoided if you have diabetes, as it may cause peripheral edema (swelling of hands and feet).

The side effects of Pregabalin 150mg Capsule may include:

• Dizziness and sleepiness
• Blurred vision or double vision
• Dry mouth
• Weight gain
• Swelling in hands and feet
• Difficulty in concentration
• Increased appetite
• Confusion

Following are the precautions and warnings for Pregabalin 150mg Capsule:

• This medication may cause dizziness and drowsiness, so patients should avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until they know how the medication affects them.
• Pregabalin may cause visual disturbances; if you experience any changes in vision, contact your doctor immediately.
• Elderly patients should use this medication with caution as they may be more sensitive to its side effects.
• It should be used with caution in individuals with a history of substance abuse or addiction, as there is a potential for misuse and dependence.
• Patients with diabetes should monitor their blood glucose levels regularly as pregabalin may affect blood sugar control.
• Pregabalin can cause weight gain, edema, and peripheral swelling; regular monitoring and lifestyle modifications may be necessary.
• Discontinue the medication gradually as directed by your healthcare provider to minimize the risk of withdrawal symptoms.

Following are the drug interactions for Pregabalin 150mg Capsule:

• Co-administration with CNS depressants like opioids, benzodiazepines, or alcohol can enhance sedation and respiratory depression.
• Therapeutic effects of Pregabalin may be reduced by certain anticonvulsants like Phenytoin and Carbamazepine.
• Drugs that lower blood pressure, such as ACE inhibitors or diuretics, may have additive hypotensive effects when used with Pregabalin.
• When combined with Lithium, Pregabalin may increase Lithium levels, requiring monitoring and dose adjustments.
• Antacids may decrease the absorption of Pregabalin, leading to reduced effectiveness.
• Pregabalin can increase the concentration of Oxycodone, potentially enhancing its effects and side effects.
• The risk of respiratory depression and sedation is increased when Pregabalin is used with other medications that cause respiratory depression, such as Morphine.

Following are the food interactions for Pregabalin 150mg Capsule:

• Alcohol consumption should be avoided as it can enhance the sedative effects of Pregabalin, leading to increased drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Pregabalin, potentially increasing its levels in the blood and the risk of side effects.
• Avoid high-fat meals as they may slightly decrease the absorption of Pregabalin, although this interaction is not considered clinically significant.
• Pregabalin can be taken with or without food, but maintaining a consistent routine is recommended for optimal absorption.
• Avoid caffeine or reduce intake as Pregabalin may enhance the effects of caffeine, leading to increased nervousness and restlessness.
• Be cautious with sugary foods as Pregabalin may alter blood glucose levels, and monitoring blood sugar is advisable for diabetic patients.
• No significant interactions with specific food groups have been reported, but maintaining a balanced diet is essential for overall health.
• Always follow the advice of your healthcare provider regarding dietary considerations while taking Pregabalin.

Pregabalin 150mg capsules should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to avoid exposure to heat, so steer clear of storage areas near ovens or radiators. Regularly check the expiration date, and properly dispose of any unused or expired capsules. Do not dispose of them via toilet or drainage systems; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

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Following are the quick tips for Pregabalin 150mg Capsule:

• Take the capsule as directed by your doctor, typically 2-3 times daily.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication.
• Avoid alcohol consumption while on this medication.
• Inform your doctor about all medications/supplements you're taking.
• Store the capsules in a cool, dry place, away from sunlight.
• Do not share this medication with others, even with similar symptoms.
• Regularly monitor kidney function and blood cell counts while on this medication.