Zinacef (750mg) 1 Injection

Cefuroxime injection, a second-generation cephalosporin antibiotic, exerts its antibacterial effect by inhibiting the synthesis of the bacterial cell wall. It achieves this through the binding of its beta-lactam moiety to specific penicillin-binding proteins (PBPs) located within the bacterial cell wall. This binding interferes with the transpeptidation reaction, which is crucial for cross-linking peptidoglycan strands, ultimately leading to the weakening and lysis of the bacterial cell wall. Cefuroxime has a broad spectrum of activity, encompassing many Gram-positive and Gram-negative bacteria, including Streptococcus, Staphylococcus, and various Enterobacteriaceae species. The mechanism of action of cefuroxime is specific to the bacterial cell wall synthesis process, making it effective against susceptible organisms while minimizing effects on human cells, which lack a similar cell wall structure.

Cefuroxime

Cephalosporin antibiotic.

injection

The following are the uses of Cefuroxime Injection:

• Used for treating bacterial infections such as pneumonia, bronchitis, and tonsillitis.
• Used for skin and soft tissue infections, including cellulitis and impetigo.
• Effective against urinary tract infections, including bladder and kidney infections.
• Used to manage severe cases of otitis media (middle ear infection) in children.
• Treats bacterial gastroenteritis, reducing symptoms and preventing complications.
• May be utilized for the prevention of infections during surgical procedures.

To be used as per doctor's advice

In the case of an overdose of Cefuroxime Injection, symptoms may include nausea, vomiting, diarrhea, and potential neurological effects such as dizziness or seizures. Prompt medical attention is required, and healthcare professionals should be contacted immediately. Treatment for overdose may involve supportive care, monitoring vital signs, and managing any adverse reactions. It is crucial to seek medical advice if there is any concern about an overdose to ensure appropriate management and prevent potential complications.

In the case of a missed dose of Cefuroxime Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Never double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for guidance on how to proceed and ensure you are still receiving the full therapeutic benefits of the medication.

To administer Cefuroxime Injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, inject the prescribed dose slowly, and then gently withdraw the needle, applying pressure with a sterile gauze pad if needed.

Here are the conditions and situations when Cefuroxime Injection should not be used:

• Must not be administered to individuals with a confirmed allergy to Cefuroxime or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe or immediate hypersensitivity reactions to beta-lactam antibiotics.
• Should not be used in patients with confirmed or suspected infectious mononucleosis.
• Not recommended for patients with severe renal impairment without appropriate dosage adjustments.
• Avoid using in patients with a history of severe gastrointestinal diseases, especially colitis or antibiotic-associated colitis.
• Not suitable for patients with a history of seizures or conditions that lower the seizure threshold.
• Contraindicated in newborn infants with hyperbilirubinemia or in premature newborns.

The side effects of Cefuroxime Injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rashes or itching
• Dizziness
• Headache
• Pain or inflammation at the injection site
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Changes in liver function tests

Here are the precautions and warnings for Cefuroxime Injection:

• This medication should not be administered to individuals with a known allergy to Cefuroxime or other cephalosporin antibiotics.
• Renal function should be monitored during prolonged treatment, especially in patients with pre-existing kidney issues.
• Cefuroxime should be used with caution in patients with a history of gastrointestinal diseases, as it may cause gastrointestinal disturbances.
• Patients with a history of seizures or conditions that increase seizure risk should be closely monitored, as Cefuroxime may lower the seizure threshold.
• Caution is advised in patients with a history of hematological disorders, as Cefuroxime can affect blood cell counts.
• This medication should be used with care in elderly patients, as they may be more susceptible to its side effects.
• Cefuroxime should not be mixed with other drugs in the same syringe or infusion bag unless physically and chemically compatible.

Following are the drug interactions for Cefuroxime Injection:

• Probenecid can reduce the elimination of cefuroxime, leading to increased drug levels and potential toxicity.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, diuretics) may increase the risk of kidney damage.
• Cefuroxime may decrease the effectiveness of hormonal contraceptives, requiring additional contraceptive measures.
• Antacids containing aluminum, magnesium, or calcium can reduce the absorption of cefuroxime when taken simultaneously.
• Methotrexate levels may be elevated when used with cefuroxime, increasing the risk of methotrexate toxicity.
• The efficacy of live attenuated vaccines (e.g., measles, mumps, rubella) may be diminished during and shortly after cefuroxime treatment.
• Drugs that affect renal function or compete for renal tubular secretion may influence the elimination of cefuroxime.

Following are the food interactions for Cefuroxime Injection:

• Avoid consuming alcohol during the treatment with Cefuroxime as it may increase the risk of gastrointestinal side effects and potentially impact the effectiveness of the medication.
• Cefuroxime should be administered on an empty stomach, preferably 1 hour before or 2 hours after meals, to ensure optimal absorption.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Cefuroxime, potentially altering its effectiveness.
• Avoid high-fat meals as they may delay the absorption of Cefuroxime, leading to reduced effectiveness.
• There is no significant interaction with dairy products, but it's best to maintain a consistent diet while on this medication.
• Avoid using salt substitutes or potassium-rich foods without medical advice as Cefuroxime can affect potassium levels.
• Always inform your healthcare provider about your dietary habits to ensure the medication's effectiveness and minimize potential interactions.

Cefuroxime Injection should be stored in a controlled environment, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from light and moisture by keeping it in its original packaging or a sealed container. Avoid storing it in the refrigerator or exposing it to freezing temperatures as this may affect the medication's potency. Always check the expiration date before use, and do not use the injection if it has expired. When it comes to disposal, do not throw away unused or expired Cefuroxime Injection in regular household trash or flush it down the toilet. Instead, follow local guidelines for the safe disposal of medications, or consult a healthcare professional or pharmacist for guidance on proper disposal methods. Keep this medication out of the reach of children and pets to prevent accidental exposure.

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Following are the quick tips for Cefuroxime Injection:

• Administer the injection as prescribed by your doctor, ensuring the prescribed dosage and frequency.
• Cefuroxime injection should be given intramuscularly or intravenously as directed by your healthcare professional.
• Ensure the injection is given into the muscle or vein slowly and completely to prevent leakage.
• Do not inject into areas with active skin infections or injuries.
• Rotate injection sites to minimize tissue irritation.
• If you experience pain or irritation at the injection site, inform your healthcare provider.
• Properly dispose of used needles and syringes in designated sharps containers.