Zolid Plus (15/500mg) 28 Tablets

The combination of Metformin 500mg and Pioglitazone 15mg in a single tablet has a synergistic mechanism of action to control blood sugar levels. Metformin primarily works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits gluconeogenesis and decreases intestinal absorption of glucose, leading to lower blood glucose levels. Pioglitazone, on the other hand, belongs to the thiazolidinedione class and acts as an insulin sensitizer. It activates specific nuclear receptors called peroxisome proliferator-activated receptors (PPARs), particularly PPAR-gamma, which are found in adipose tissue, liver, and muscle. This activation enhances insulin sensitivity by improving glucose uptake and utilization in these tissues, thereby reducing insulin resistance and lowering blood sugar levels. Together, these two components provide a dual approach to managing blood glucose by targeting both glucose production and insulin sensitivity.

Biguanide and Thiazolidinedione.

Tablet

The following are the uses of Metformin 500mg, Pioglitazone 15mg Tablet:

• Used for treating Type 2 Diabetes by lowering blood sugar levels.
• Used to improve insulin sensitivity, allowing better glucose absorption.
• Used to reduce the risk of diabetes-related complications.
• Used for managing blood sugar levels when diet and exercise are not enough.
• Used to enhance the body's response to insulin.
• Used to potentially aid in weight loss and improve cardiovascular health.
• Used as part of a comprehensive diabetes management plan.
• Used to stabilize long-term blood sugar control.

To be determined by the doctor

In the case of an overdose of Metformin 500mg and Pioglitazone 15mg, the patient may experience symptoms such as nausea, vomiting, abdominal pain, and dizziness. Severe cases can lead to lactic acidosis, characterized by deep, rapid breathing, weakness, and fatigue. It is crucial to seek medical assistance promptly, as timely intervention can help manage symptoms and prevent potential complications. Contact a healthcare professional or emergency services for guidance on the appropriate steps to take.

In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Pioglitazone 15mg Tablet, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It's important to maintain a consistent medication routine for effective blood sugar control.

To take Metformin 500mg and Pioglitazone 15mg tablets, swallow one tablet with a full glass of water, preferably during or after a meal, exactly as prescribed by your healthcare provider, typically once or twice a day.

Following are the conditions/situations when Metformin 500mg and Pioglitazone 15mg Tablet should not be taken:

• Should not be used in patients with a known allergy to Metformin, Pioglitazone, or any of the tablet's components.
• Contraindicated in patients with a history of diabetic ketoacidosis.
• Not suitable for individuals with severe kidney disease or kidney failure.
• Should not be used in patients with severe liver disease or liver failure.
• Contraindicated in patients with a history of heart failure or those with a recent heart attack.
• Not recommended for individuals with respiratory conditions such as severe chronic obstructive pulmonary disease (COPD) or severe asthma.
• Should not be taken if you have a history of bladder cancer or are undergoing bladder cancer treatment.
• Avoid if you have an acute or severe infection, trauma, or severe stress, as it may temporarily impair your ability to metabolize the medication.
• Not suitable for individuals with diabetic eye disease or vision loss due to diabetes.

The side effects of Metformin 500mg, Pioglitazone 15mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Loss of appetite
• Weight gain
• Swelling of the arms, legs, or feet
• Liver problems (rare)
• Blurred vision or other visual disturbances

Following are the precautions and warnings for Metformin 500mg, Pioglitazone 15mg Tablet:

• Avoid if allergic to any component of the tablet; seek medical attention if you experience symptoms like rash, itching, or difficulty breathing.
• Regular monitoring of kidney function is necessary, especially in older adults, as Metformin can rarely cause lactic acidosis.
• Patients with liver problems should exercise caution, as Pioglitazone may affect liver function.
• Inform your doctor about any heart-related issues, as Pioglitazone can lead to fluid retention and heart failure.
• This medication may increase the risk of bone fractures, especially in women. Regular bone density monitoring is advised.
• Avoid excessive alcohol consumption while on this medication as it may increase the risk of lactic acidosis.
• Inform your doctor if you have a history of bladder cancer or are undergoing surgery, as Pioglitazone may need to be temporarily stopped.
• Patients with a history of eye problems, particularly edema, should have regular eye examinations.

Following are the drug interactions for Metformin 500mg, Pioglitazone 15mg Tablet:

• Concomitant use with insulin or other oral antidiabetic drugs may require dose adjustment of either drug to maintain blood glucose control.
• Furosemide and other loop diuretics can decrease the renal excretion of metformin, potentially leading to increased metformin levels.
• Pioglitazone may enhance the effects of sulfonylureas and insulin, increasing the risk of hypoglycemia.
• The risk of lactic acidosis is higher when used with other drugs that can cause this condition, such as certain HIV medications.
• Corticosteroids and beta-2 agonists may reduce the blood glucose-lowering effect of metformin and pioglitazone.
• Isoniazid can increase blood glucose levels and may reduce the effectiveness of metformin and pioglitazone.
• Drugs that affect liver function, like rifampicin, can alter the metabolism of pioglitazone.

Following are the food interactions for Metformin 500mg, Pioglitazone 15mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a rare but serious side effect of Metformin.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the blood sugar-lowering effect of Pioglitazone, potentially leading to hypoglycemia.
• Fatty foods can affect the absorption of Pioglitazone, so it is best to take the medication on an empty stomach or with a light meal.
• Avoid high-fat meals as they can increase the absorption of Pioglitazone, potentially leading to higher blood levels of the drug.
• Limit caffeine intake, as it can increase blood pressure and heart rate, which may interact with the blood pressure-lowering effects of Pioglitazone.
• Be cautious with high-sugar foods, as Pioglitazone can enhance the body's response to insulin, potentially causing hypoglycemia if sugar intake is not carefully monitored.
• A balanced diet with consistent carbohydrate intake is recommended to maintain stable blood sugar levels while taking this medication.
• Always follow the dietary advice provided by your healthcare professional for optimal management of your condition.

Metformin 500mg, Pioglitazone 15mg Tablets should be stored in a cool and dry place, preferably at room temperature (around 20-25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is crucial to store medications away from direct sunlight, heat, and sources of moisture. Always check the expiration date on the packaging, and do not use the tablets beyond their expiry date. For disposal, do not throw the medication in the trash or flush it down the toilet. Consult your pharmacist or local waste management authority for specific guidelines on how to safely dispose of unused or expired medication, ensuring that it does not harm the environment or pose a risk to others. Keep the tablets out of the sight and reach of children to prevent accidental ingestion.

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Following are the quick tips for Metformin 500mg, Pioglitazone 15mg Tablet:

• Always take the medication as directed by your doctor; do not alter the dosage without medical advice.
• Take the tablet with a full glass of water to facilitate swallowing and prevent irritation.
• Maintain a consistent schedule for taking the medication, preferably with meals.
• Do not break, crush, or chew the tablet; swallow it whole for optimal absorption.
• Regularly monitor your blood sugar levels as instructed by your healthcare provider.
• Inform your doctor about any other medications or supplements you are taking.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.