Zolid Plus (15/850mg) 14 Tablets

The combination of Metformin 850mg and Pioglitazone 15mg in a tablet form has a synergistic mechanism of action to control blood sugar levels. Metformin primarily works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits gluconeogenesis and decreases intestinal absorption of glucose, leading to lower blood glucose levels. Pioglitazone, on the other hand, is a thiazolidinedione (TZD) that acts as an insulin sensitizer. It activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in adipose tissue, muscle, and liver cells, which increases insulin sensitivity and glucose uptake in these tissues. This activation also reduces insulin resistance and improves overall glucose metabolism. Together, these mechanisms contribute to better glycemic control and are particularly effective in managing type 2 diabetes mellitus.

Biguanide/Thiazolidinedione combination.

Tablet

The following are the uses of Metformin 850mg, Pioglitazone 15mg Tablet:

• Used for treating type 2 diabetes, especially when diet and exercise alone are not effective in controlling blood sugar levels.
• Used to help lower blood glucose levels by improving insulin sensitivity.
• Used to enhance the body's response to its naturally produced insulin.
• Used to reduce the amount of glucose released into the bloodstream from the liver.
• Used to improve glycemic control, thereby preventing long-term complications associated with diabetes.
• Used as an adjunct to a healthy diet and regular exercise regimen for better diabetes management.
• Used to potentially delay the progression of prediabetes to type 2 diabetes in certain individuals.

To be determined by the doctor

In the case of an overdose of Metformin 850mg and Pioglitazone 15mg tablets, it is important to recognize the potential risks. These medications, when taken in excess, can lead to severe side effects. Symptoms may include nausea, vomiting, dizziness, and in severe cases, lactic acidosis. It is crucial to seek medical advice promptly and provide detailed information about the quantity consumed, ensuring appropriate treatment and management of any adverse reactions.

In the case of a missed dose of Metformin 850mg, take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. For Pioglitazone 15mg Tablet, if you miss a dose, take it as soon as you remember, unless it is close to the time of your next dose. In this case, skip the missed dose and continue with your regular dosing schedule. It is important not to miss doses of these medications, but if you do, consult your healthcare provider for further guidance.

To take the Metformin 850mg and Pioglitazone 15mg Tablet, swallow one tablet with a full glass of water during a meal or as directed by your healthcare provider, typically twice a day, to ensure proper absorption and minimize gastrointestinal side effects.

Here are the conditions or situations when Metformin 850mg and Pioglitazone 15mg Tablet should not be taken:

• Not suitable for patients with a known allergy to Metformin or Pioglitazone, or any other ingredients in the tablet.
• Contraindicated in patients with diabetic ketoacidosis.
• Should not be used in patients with severe kidney disease or kidney failure.
• Not recommended for individuals with severe liver impairment or liver disease.
• Should be avoided in patients with a history of heart failure or cardiac issues.
• Not suitable for patients with respiratory diseases such as severe chronic obstructive pulmonary disease (COPD).
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for children below 18 years of age.
• Should be used with caution in patients with vitamin B12 deficiency or anemia.
• Avoid if you have a history of bladder cancer or are undergoing bladder surgery.

The side effects of Metformin 850mg, Pioglitazone 15mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or constipation
• Metallic taste in the mouth
• Increased thirst or dry mouth
• Weight gain
• Swelling in the arms or legs
• Liver-related issues (rare)

Following are the precautions and warnings for Metformin 850mg, Pioglitazone 15mg Tablet:

• Patients with a known allergy to Metformin or Pioglitazone should not take this medication.
• Regular monitoring of liver function is necessary, and if liver problems occur, the drug should be discontinued.
• Not recommended for patients with severe heart failure or at risk of heart failure.
• Patients with kidney disease should exercise caution, and dosage adjustments might be required based on kidney function.
• May cause fluid retention, leading to or worsening heart failure. Close monitoring is essential.
• Not suitable for patients with bladder cancer or a history of bladder cancer.
• Alcohol consumption should be avoided or limited while taking this medication as it may increase the risk of lactic acidosis.
• Patients should inform their doctor if they have a history of heart, liver, or kidney disease before starting this medication.

Following are the drug interactions for Metformin 850mg and Pioglitazone 15mg Tablet:

• Alcohol consumption can increase the risk of lactic acidosis with metformin. Avoid or limit alcohol intake.
• Pioglitazone may enhance the effects of insulin and other antidiabetic medications, leading to hypoglycemia. Dose adjustments may be necessary.
• NSAIDs (e.g., ibuprofen) can reduce the effectiveness of pioglitazone, requiring careful monitoring of blood glucose levels.
• Corticosteroids can increase blood glucose levels, and their use with metformin and pioglitazone may require adjustments in antidiabetic therapy.
• Certain medications like rifampicin can decrease the effectiveness of pioglitazone by increasing its metabolism.
• Metformin may interact with contrast agents used in imaging procedures, increasing the risk of kidney damage. Temporary discontinuation may be recommended.
• Caution is advised when using with other medications that can cause fluid retention, as pioglitazone may exacerbate this effect.

Following are the food interactions for Metformin 850mg and Pioglitazone 15mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a serious side effect associated with Metformin.
• Limit or avoid grapefruit and grapefruit juice as they can affect the breakdown of Pioglitazone, leading to increased drug levels and potential side effects.
• Monitor blood glucose levels when consuming high-sugar foods or beverages, as Metformin and Pioglitazone may not control blood sugar effectively when paired with high-sugar diets.
• Avoid or limit the intake of fatty or fried foods, as Pioglitazone may increase the risk of fluid retention and heart-related issues when combined with a high-fat diet.
• Avoid vitamin B12 deficiency by ensuring an adequate intake of vitamin B12-rich foods, as long-term Metformin use can decrease its absorption.
• Be cautious with high-salt foods, as Pioglitazone may increase the risk of fluid retention and swelling, especially in individuals with heart or kidney issues.
• Consult a healthcare provider about dietary adjustments, especially if you have a history of liver or kidney problems, as these organs play a role in metabolizing these medications.
• No significant food interactions have been reported to directly impact the absorption of Metformin and Pioglitazone, but it's advisable to follow healthcare professionals' recommendations.

Metformin 850mg, Pioglitazone 15mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication should be kept in its original container with the lid tightly secured to maintain its integrity. It is crucial to avoid exposing the tablets to extreme temperatures, so steer clear of storing them in the bathroom or near heat-emitting appliances. Always adhere to the expiration date on the packaging, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it in toilets or drains; instead, seek guidance from a pharmacist or healthcare professional for the recommended disposal method. Additionally, keep the medication out of children's reach to prevent accidental ingestion.

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Following are the quick tips for Metformin 850mg and Pioglitazone 15mg Tablet:

• Consult your doctor before starting this medication and provide a complete medical history.
• Take the tablet as directed, usually once or twice daily with meals.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule and do not skip doses.
• Regularly monitor your blood sugar levels as advised by your doctor.
• Inform your doctor about all other medications you are taking to prevent potential drug interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.