Zylexx SR (75mg) 20 Tablets

Bupropion 75mg Tablet primarily acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It works by blocking the reabsorption of two key neurotransmitters, norepinephrine and dopamine, in the brain. This inhibition increases the levels of these neurotransmitters in the synaptic cleft, leading to enhanced neurotransmission. Norepinephrine is associated with alertness and energy, while dopamine is linked to motivation, pleasure, and attention. By elevating the levels of these neurotransmitters, bupropion can improve mood, increase motivation, and reduce cravings, making it effective in treating depression and aiding in smoking cessation.

Bupropion 75mg

Antidepressant

Tablet

The following are the uses of Bupropion 75mg Tablet:

• Used for treating depression and helping to improve mood, energy levels, and overall well-being.
• Used for supporting smoking cessation by reducing cravings and withdrawal symptoms.
• Used for managing seasonal affective disorder (SAD) by regulating mood during winter months.
• Used for treating attention-deficit/hyperactivity disorder (ADHD) to improve focus and concentration.
• Used for assisting with weight loss by suppressing appetite and increasing energy expenditure.
• Used for managing premenstrual dysphoric disorder (PMDD) symptoms.
• Used for certain types of treatment-resistant depression when combined with other medications.

In the case of an overdose of Bupropion 75mg Tablets, several symptoms may occur, including seizures, rapid heartbeat, confusion, and hallucinations. It is important to seek medical assistance promptly if an overdose is suspected. The treatment for overdose involves managing these symptoms and may require hospitalization for monitoring and supportive care. Timely intervention can help mitigate the risks associated with Bupropion overdose. Always consult healthcare professionals for specific guidance and treatment options.

In the case of a missed dose of Bupropion 75mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time for your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication.

To take Bupropion 75mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, and ensure you follow the prescribed dosage and duration of treatment.

Following are the conditions or situations when Bupropion 75mg Tablet should not be taken:

• Avoid if you have a history of seizures or convulsions, as it can lower the seizure threshold.
• Do not use if you have an eating disorder such as anorexia or bulimia.
• Contraindicated in individuals with a recent history of a heart attack or those with severe heart-related conditions.
• Should not be taken if you have a tumor in the nervous system (neuroleptic malignant syndrome).
• Not suitable for individuals who are in a manic phase of bipolar disorder.
• Avoid if you have suddenly stopped using alcohol, seizure medicines, or sedatives, as it can increase the risk of seizures.
• Do not use if you have a history of head injury or brain trauma.

The side effects of Bupropion 75mg Tablet may include:

• Nausea and vomiting
• Dry mouth
• Headache
• Dizziness
• Insomnia (difficulty in sleeping)
• Anxiety
• Skin rashes
• Increased heart rate

Following are the precautions and warnings for Bupropion 75mg Tablet:

• Not suitable for individuals with a history of seizures or eating disorders, as Bupropion can lower the seizure threshold.
• Patients with a history of bipolar disorder or mania should exercise caution, as Bupropion may trigger manic episodes.
• Patients with liver or kidney disease should be closely monitored as Bupropion is metabolized by the liver and excreted by the kidneys.
• Alcohol consumption should be avoided as it can increase the risk of seizures and liver-related side effects.
• Not recommended for patients with a history of head injury or brain tumor due to the risk of increased intracranial pressure.
• May cause allergic reactions; seek medical attention if you experience symptoms like rash, itching, or swelling.
• Patients should be aware of potential changes in behavior and mood, and any such changes should be reported to a healthcare professional immediately.
• Store Bupropion tablets in a secure place, out of reach of children and pets, to prevent accidental ingestion.

Following are the drug interactions for Bupropion 75mg Tablet:

• Bupropion can lower the seizure threshold; its use with other medications that lower this threshold, such as antipsychotics, tramadol, or other antidepressants, increases the risk of seizures.
• Combining Bupropion with other noradrenergic and dopaminergic drugs (e.g., amphetamines, methylphenidate) can raise blood pressure and heart rate, increasing the risk of cardiovascular events.
• The effectiveness of Bupropion may be reduced when used with certain anticonvulsants like carbamazepine or phenytoin, as these drugs can induce its metabolism.
• Caution is advised when using Bupropion with medications metabolized by CYP2D6, as it may inhibit this enzyme, leading to increased levels of these drugs.
• Bupropion may increase the risk of hypertension when taken with sympathomimetic agents like epinephrine or norepinephrine.
• It can interact with nicotine replacement therapy, potentially increasing the risk of hypertension and cardiovascular side effects.
• Use with other antidepressants or CNS stimulants may increase the risk of neurologic side effects and psychosis.

Following are the food interactions for Bupropion 75mg Tablet:

• Avoid excessive caffeine intake as it can increase the risk of seizures, especially in patients with a history of seizures or conditions that lower the seizure threshold.
• Alcohol consumption should be limited or avoided as it can enhance the effects of Bupropion, leading to increased side effects like dizziness, sleepiness, and impaired judgment.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Bupropion, potentially leading to increased drug levels in the body.
• Avoid high-fat meals as they may affect the absorption and bioavailability of Bupropion, possibly altering its effectiveness.
• Be cautious with foods containing tyramine (aged cheeses, cured meats, fermented foods) as Bupropion can potentially interact with these, leading to increased blood pressure.
• Consuming large amounts of high-tyramine foods should be avoided to prevent potential blood pressure spikes.
• No significant food interactions are known to directly impact the absorption of Bupropion, but it's best to consult your healthcare provider for personalized advice.
• Always follow the prescribed dosage and schedule for optimal results and minimal food-related interactions.

Bupropion 75mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (68°F to 77°F). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial not to store them in the bathroom or kitchen, as these areas can expose the medication to heat and humidity. Always check the expiration date, and if the tablets are expired or no longer needed, proper disposal is essential. Do not throw them into the trash or flush them down the toilet; instead, follow local guidelines for medication disposal or consult a pharmacist for advice on how to safely discard the tablets to prevent any potential harm to the environment. Keep the medication out of children's reach to ensure their safety.

Following are the quick tips for Bupropion 75mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor.
• Swallow the tablet whole, do not crush or chew.
• Take the tablet at the same time each day to maintain a consistent level in your system.
• Do not stop taking the medication abruptly, consult your doctor for a proper tapering schedule.
• Avoid alcohol consumption while on this medication.
• Inform your doctor about all medications and supplements you are taking.
• Store the medication in a cool, dry place, away from direct sunlight.